金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: ZIP4H/Tex11 Long Name: Zinc Transporter Protein 4 Homolog Aliases: Tex11; TGC1; TSGA3 Entrez Gene IDs: 56159 (Human); 83558 (Mouse); 501588 (Rat) Background: ZIP4H ZIP4 homolog (ZIP4H), also known as Testis expressed sequence 11 /Tex11, is an X chromosome-encoded protein that is selectively expressed in primordial male germ cells. It associates with Nbs1 of the Mre11 protein complex which results in localization to areas of synaptonemal contact between meiotic chromosomes. During meiosis, ZIP4H promotes sister chromatid synapsis and crossover in response to programmed double stranded DNA breaks. ZIP4H deficiency leads to increased spermatocyte apoptosis and male sterility.