R&D Systems代理MAB40401 Human/Mouse TSC2 MAb (Clone 614204) (100 UG)-试剂-金山科研平台

R&D Systems代理MAB40401 Human/Mouse TSC2 MAb (Clone 614204) (100 UG)

2025-06-28

货号：MAB40401

品牌：R&D Systems

规格：100ug

目录价：￥3720.00

市场价格：￥2976.00

会员价格：￥2976.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: TSC2 Long Name: Tuberous Sclerosis 2 Aliases: LAM; TSC4; Tuberin Entrez Gene IDs: 7249 (Human); 22084 (Mouse); 24855 (Rat) Background: TSC2

View TSC2 IHC images. TSC2, also called tuberin, complexes with TSC1 (hamartin) to inhibit cell proliferation by antagonizing mTOR/p70S6K signaling.Its location either in the cytoplasm or the nucleus is regulated by phosphorylation and the cell cycle. Numerous point mutations are associated with development of tumors (hamartomas) in kidney, heart, skin and brain. Human TSC2 shares 91% amino acid (aa) identity with mouse TSC2 over aa 550-850. Splice variants that are missing aa 946 to 988 or 989 may show different tissue distribution than full length TSC2.

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