货号：AG992

品牌：Merck Millipore

规格：

目录价：￥2693.00

市场价格：￥2289.05

会员价格：￥2154.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: LRRK2 Control Peptide View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 100 µg View All» Key Applications: Peptide Inhibition Assay View All» Application Notes: Antibody blocking (AB9682) Optimal working concentration must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. View All» UniProt Summary: FUNCTION: SwissProt: Q5S007 # Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity.SIZE: 2527 amino acids; 286058 Da SUBUNIT: Interacts with PARK2.SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.TISSUE SPECIFICITY: Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.DISEASE: SwissProt: Q5S007 # Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8) [MIM:607060, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late- onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.SIMILARITY: SwissProt: Q5S007 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 16 LRR (leucine-rich) repeats. & Contains 1 Miro domain. & Contains 1 protein kinase domain. View All» Species: Rat View All» Brand Family: Chemicon View All» Presentation: Liquid. View All» UniProt Number: Q5S007 View All» Storage Conditions: Store at -207deg;C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. View All» Gene Symbol:

• LRRK2

• RIPK7

• ROCO2

• dardarin

• PARK8

• DKFZp434H2111

• AURA17

• FLJ45829

• Dardarin

• EC 2.7.11.1
  View All» Product Name: LRRK2 Control Peptide View All» Entrez Gene Number: NM_198578.2 View All» Alternate Names: leucine-rich repeat kinase 2, Dardarin View All» Concentration: 1 mg/mL View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://16ao.com/thread-160192.htm
  © Merck Millipore代理AG992 LRRK2 CONT PEPTIDE (AB9682)-100UG，产品报价联系微信jinshanbio