货号：AG906

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MMP-18 View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 250 µL View All» Product Overview: AG906 is provided as concentrated conditioned cell culture media, for use in Western blotting applications and in substrate zymography. The product contains variable amounts of MMP-18, and is intended as a qualitative control. View All» Key Applications: Positive Control View All» Application Notes: Western Blotting: 20-40 μL Optimal working dilution must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has a role in cellular proliferation as well as migration and adhesion to type I collagen. Multiple transcript variants encoding distict isoforms have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q99542 # Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).SIZE: 508 amino acids; 57357 Da SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).TISSUE SPECIFICITY: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.DOMAIN:SwissProt: Q99542 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM: Activated by autolytic cleavage after Lys-97.DISEASE:SwissProt: Q99542 # May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains. View All» Species: Xenopus View All» Brand Family: Chemicon View All» Presentation: Concentrated serum free culture media from cells treated with the phorbol ester, TPA. The media contains Xenopus collagenase-4 (MMP-18). View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. View All» Gene Symbol:

• MMP19

• RASI

• MMP-19

• MMP18

• MMP-18

• RASI-1

• EC 3.4.24.-
  View All» Product Name: MMP-18 View All» Alternate Names: Collagenase-4 View All» UniProt Number: Q99542 View All» Entrez Gene Number:
  • NM_001032360.1

  • NM_002429.4
    View All»
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