货号：AG782

品牌：Merck Millipore

规格：1unit

目录价：￥5845.00

市场价格：￥4968.25

会员价格：￥4676.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Angiotensin Converting Enzyme, rat View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 1 unit View All» Product Overview: ACE (kininase II, EC 3.4.15.1) is a zinc dipeptidyl carboxypeptidase. ACE catalyses both angiotensin I transformation to angiotensis II (a potent vasopressor agent) and degradation of bradikinin, a vaso-depressor. ACE appears to play a key role in regulating vascular tone and remodeling the development of atherosclerotic lesions. Increasing evidence suggests that ACE plays an important role in vascular pathology.Recent studies shows two new functions of this important enzyme: 1) ACE enhances the presentation of endogenous antigens (in particularly HIV 1 gp160-derived peptide p18) to MHC class I-restricted T-lynphocytes (ref. 1); 2) amino-terminal domain of ACE cleaves effectively hemoregulatory tetrapeptide N-Ac-Ser-Asp-Lys-Pro (ref. 2,3) which is involved in the control of hemapoetic stem cell proliferation (the amount of this peptide greatly decreases in patients undergoing cancer chemotherapy) (ref. 4). View All» Key Applications: Positive Control View All» Application Notes: As a reference in SDS-PAGE and Western blotting [together with anti-ACE monoclonal (MAB4051) also available from Chemicon]. For Western blotting 500 ng/lane if gel is developed with anti-ACE MAB4051. As a reference antigen for immunoprecipitation of ACE from various tissue samples (in combination with anti-ACE MAB4051). As a source of pure ACE for different enzymatic studies of ACE (testing of ACE inhibitors, substrate specificity, kinetic measurements, etc.). Optimal working concentration must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Rat View All» Brand Family: Chemicon View All» Source: Isolated from rat lung using affinity chromatography (ref. 5). View All» Presentation: Liquid in 100 mM phosphate buffered saline, 150 mM NaCl, pH 7.4 with 0.2mM CHAPS. Purity is >95% by SDS-PAGE when 10 μg was loaded. Contains no preservative. View All» UniProt Number: P47820 View All» Specific Activity: 7.3 mU per μg of protein (One unit will produce 1 μMole of hippuric acid or His-Leu from Z-Phe-His-Leu per minute in 0.1M phosphate buffer and 300 mM NaCl at pH 8.3 at 37°C). View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» Gene Symbol:

• ACE

• DCP1
  View All» Product Name: Angiotensin Converting Enzyme, rat View All» Alternate Names: ACE; CD143; DCP1; Peptidyl-dipeptidase A; Peptidase P View All» Concentration: 360 μg/mL View All»
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