金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: MKP-3 Long Name: MAP Kinase Phosphatase 3 Aliases: DUSP6; PYST1 Entrez Gene IDs: 1848 (Human) Background: MKP-3 MKP-3, also called PYST1 and dual specificity phosphatase 6 (DUSP6), dephosphorylates serine, threonine, and tyrosine residues in proteins. It has a high degree of substrate selectivity for dephosphorylating ERK kinases over stress-related kinases such as p38 and JNK. MKP-3 is ubiquitinylated prior to degradation in the proteosome. The rate of MKP-3 degradation is enhanced by ERK-mediated phosphorylation.