货号：AG305

品牌：Merck Millipore

规格：

目录价：￥2188.00

市场价格：￥1859.80

会员价格：￥1750.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Glutamate Receptor 2 & 3, control peptide for AB1506 View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: Peptide from the carboxy terminus of rat GluR2. View All» Key Applications: Cell Function Assay View All» Application Notes: For use in blocking the reactivity of AB1506. Optimal working dilution must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P42262 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.SIZE: 883 amino acids; 98821 Da SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity).SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).SIMILARITY: SwissProt: P42262 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. View All» Species: Rat View All» Brand Family: Chemicon View All» Presentation: Liquid in water. Contains no preservative. View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Gene Symbol:

• GRIA2

• GluR-B

• gluR-B

• GluR-2

• HBGR2

• GluR-K2

• GLUR2

• GLURB
  View All» Product Name: Glutamate Receptor 2 & 3, control peptide for AB1506 View All» Alternate Names: GluR2/3 View All» Concentration: 1.0 mg/mL View All» UniProt Number: P42262 View All» Entrez Gene Number:
  • NM_000826.3

  • NM_001083619.1

  • NM_001083620.1
    View All»
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