货号：AG217

品牌：Merck Millipore

规格：100Ug

目录价：￥6626.00

市场价格：￥5632.10

会员价格：￥5300.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Histamine Receptor 4, control peptide for AB5663P View All» Trade Name: Chemicon (Millipore) View All» Qty/Pk: 100 µg View All» Product Overview: Synthetic 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4. View All» Key Applications: Cell Function Assay View All» Application Notes: For use in blocking the reactivity of AB5663P. Optimal working dilution must be determined by the end user. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors. View All» UniProt Summary: FUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).SIZE: 390 amino acids; 44496 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family. MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists." View All» Species: Human View All» Brand Family: Chemicon View All» Presentation: Liquid in PBS containing 0.1% sodium azide. View All» UniProt Number: Q9H3N8 View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Gene Symbol:

• HRH4

• MGC133027

• GPCR105

• HH4R

• GPRv53

• H4R

• H4

• AXOR35

• SP9144

• BG26
  View All» Product Name: Histamine Receptor 4, control peptide for AB5663P View All» Entrez Gene Number: NM_021624.2 View All» Concentration: 1.0 mg/mL View All»
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