金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Tyk2 Long Name: Protein tyrosine kinase 2 Entrez Gene IDs: 7297 (Human); 54721 (Mouse); 298706 (Rat) Background: Tyk2 Tyk2 belongs to the Janus family of intracellular tyrosine kinases that are activated by receptors for many cytokines. Activation of Tyk2 occurs via phosphorylation at two adjacent tyrosine residues within the kinase domain. Tyk2 is required for interferon-mediated tyrosine phosphorylation of STAT3 and interferon a receptor 1. Mice lacking Tyk2 are susceptible to parasitic infection but resistant to autoimmune arthritis.