货号：ABT58

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho PKA-RII (Ser96) Antibody | ABT58 View All» Replaces: 06-704 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes PKA-RIIalpha when phosphorylated at Ser96. View All» Molecular Weight: ~ 51 kDa MW observed. The specificity of the target was shown by Lambda phosphatase treatment. View All» Epitope: Phosphorylated Ser96 of PKA-RIIalpha View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse PKA-RIIalpha phosphorylated at Ser96. View All» Modifications: Phosphorylation View All» Background Information: cAMP-dependent protein kinase type II-alpha regulatory subunit (PKA-RIIα) is an enzymatic protein belonging to the cAMP-dependent kinase regulatory chain family, a group of regulatory proteins involved in the PKA signaling pathway. This pathway has been shown to have regulatory roles in development, growth, and mortality of various organisms. PKA-RIIα is a subunit of the PKA type II regulatory chain, one of two PKA isoforms, and is involved in the regulation of membrane interactions through its binding to anchoring proteins, such as MAP2 kinase. Before its activation with cAMP, the enzyme is comprised of two catalytic chains and two regulatory chains, which split into two catalytic monomers and one regulatory dimmer after interacting with cAMP. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and rat. Predicted to react with mouse based on 100% sequence homology. View All» Control: Forskolin untreated and treated PC12 cell lysates View All» Quality Assurance: Evaluated by Western Blot in Forskolin untreated and treated PC12 cell lysates.Western Blot Analysis: 1 µg/mL of the antibody detected PKA-RIIalpha (Ser96) in 10 µg of Forskolin untreated and treated PC12 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P12367 View All» Entrez Gene Number: NP_032950 View All» Gene Symbol:
  • PRKAR2A

  • PKR2

  • PRKAR2
    View All» Alternate Names:
    • PRKAR2A

    • protein kinase

    • cAMP-dependent, regulatory, type II, alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SUBUNIT STRUCTURE: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4. Interacts with CBFA2T3 (by similarity). TISSUE SPECIFICTY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM: Phosphorylated by the activated catalytic chain. SEQUENCE SIMILARITIES: Belongs to the cAMP-dependent kinase regulatory chain family.Contains 2 cyclic nucleotide-binding domains. View All» Product Name: Anti-phospho PKA-RII (Ser96) View All» Concentration: 0.16 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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