货号：ABT46

品牌：Merck Millipore

规格：EA

目录价：￥3673.00

市场价格：￥3122.05

会员价格：￥2938.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Kinesin-like protein KIF14 Antibody | ABT46 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~186 kDa observed. An uncharacterized band appears at ~33 kDa in some lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Kinesin-like protein KIF14. View All» Background Information: Mitotic kinesin KIF14 is a microtubule motor protein that seems to localize to developing spindle poles and spindle microtubules. Over-expression of KIF14 has also been linked to poor-prognosis breast cancer. KIF14 over-expression in retinoblastoma seems to correlate with older age and is located in the nucleus and cytoplasm of tumor cells. KIF14 has also been implicated in laryngeal carcinoma and could be a promising molecular marker. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Mouse (89% sequence homology) and Rat (78% sequence homology). View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Kinesin-like protein KIF14 in HeLa cells. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 2.5 µg/mL of this antibody detected Kinesin-like protein KIF14 in 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15058 View All» Entrez Gene Number: NP_055690 View All» Gene Symbol: KIF14 View All» Alternate Names:

• Kinesin-like protein KIF14

• KIF14
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plays an essential role in cytokinesis.SUBUNIT STRUCTURE: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23. Directly interacts with CIT depending on the activation state of the kinase (stronger interaction with the kinase-dead form). Interacts with ARRB2; the interaction is detected in the nucleus upon OR1D2 stimulation. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Nuclear localization observed during interphase in Ref.5 or triggered by entry into mitosis in Ref.7. Cytoplasmic in interphase (Ref.7) and metaphase cells (Ref.5). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. DEVELOPMENTAL STAGE: Up-regulated in cells progressing through G2/M phase. SEQUENCE SIMILARITIES: Belongs to the kinesin-like protein family.Contains 1 FHA domain.Contains 1 kinesin-motor domain.SEQUENCE CAUTION: The sequence BAA05392.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Kinesin-like protein KIF14 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://16ao.com/thread-159782.htm
    © Merck Millipore代理ABT46 Anti-Kinesin-like protein KIF14，产品报价联系微信jinshanbio