货号：ABT43

品牌：Merck Millipore

规格：100Ug

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Claudin-3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~22 kDa observed. An uncharacterized band may be observed at ~37 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Claudin-3. View All» Background Information: Claudin-3 is a member of a family of claudins that are tight junction integral membrane proteins with four transmembrane domains and two extracellular loops. Claudin-3 has been shown to be the main component in the integrity of the blood-brain barrier tight junctions and is lost during inflammation caused by experimental autoimmune encephalomyelitis. Claudin-3 over-expression has been linked to the increased aggressiveness of endometrial cancers such as uterine serous papillary carcinoma. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Control: HUVEC cell lysate View All» Quality Assurance: Evaluated by Western Blot in HUVEC cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Claudin-3 in 10 µg of HUVEC cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O15551 View All» Entrez Gene Number: NP_001297 View All» Gene Symbol:
  • CLDN3

  • CPETR2
    View All» Alternate Names:
    • Claudin-3

    • Clostridium perfringens enterotoxin receptor 2

    • CPE-R 2

    • CPE-receptor 2

    • Rat ventral prostate.1 protein homolog

    • hRVP1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity (By similarity)y.SUBUNIT STRUCTURE: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity).SUBCELLULAR LOCATION: Cell junction › tight junction (By similarity). Cell membrane; Multi-pass membrane protein (By similarity). INVOLVEMENT IN DISEASE: Note=CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.SEQUENCE SIMLARITIES: Belongs to the claudin family. View All» Product Name: Claudin-3 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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