货号：ABT31

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAM-C Antibody | ABT31 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the cytoplasmic domain of JAM-C. View All» Molecular Weight: ~35 kDa observed. An uncharacterized band may be visible at ~23 kDa in some lysates. View All» Epitope: Cytoplasmic Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human JAM-C. View All» Background Information: Junctional adhesion molecule C (JAM-C) is an adhesion molecule found at endothelial intracellular junctions that plays a role in leukocyte transendothelial migration and other inflammatory events. JAM-C seems to be important in the pathophysiology of pancreatitis and therefore could be a promising clinical target. JAM-C expression has been shown to be increased when T lymphocytes are activated. Research has shown that controlling JAM-C may also be a way of controlling pathological angiogenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rhesus Macaque

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Rhesus Macaque and Chimpanzee based on 100% sequence homology. View All» Control: Human brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human brain tissue lysate.Western Blot Analysis: 0.05 µg/mL of this antibody detected JAM-C in 10 µg of human brain tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BX67 View All» Entrez Gene Number: NP_116190 View All» Gene Symbol:
  • JAM3

  • UNQ859

  • PRO1868
    View All» Alternate Names:
    • Junctional adhesion molecule C

    • JAM-C

    • JAM-2

    • Junctional adhesion molecule 3

    • JAM-3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May participate in cell-cell adhesion distinct from tight junctions.SUBUNIT STRUCTURE: Interacts with JAM2.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (potential).TISSUE SPECIFICITY: Widely expressed. Highest expression in placenta, brain and kidney.SEQUENCE SIMILARITIES: Belongs to the immunoglobulin superfamily. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.SEQUENCE CAUTION: The sequence CAC94776.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-JAM-C View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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