货号：ABT291

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DOCK3 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~233 kDa observed. Uncharacterized bands may appear at ~17 kDa and ~50 kDa in some lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human DOCK3. View All» Background Information: Dedicator of cytokinesis3 (DOCK3) is a potential guanine nucleotide exchange factor (GEF) which activates GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of DOCK3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected DOCK3 in normal human brain and Alzheimer's brain tissues.Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected DOCK3 in A431 and HeLa cells. View All» Control: Human brain tissue lysate View All» Quality Assurance: Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DOCK3 in 10 µg of human brain tissue lysate. View All» Purification Method: Antigen Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: Q8IZD9 View All» Gene Symbol:

• DOCK3

• MOCA
  View All» Alternate Names:
  • Modifier of cell adhesion

  • dedicator of cytokinesis 3

  • Presenilin binding protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry

    • Immunocytochemistry
      View All» Product Name: Anti-DOCK3 View All» Concentration: 0.43 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 150 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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