货号：ABT27

品牌：Merck Millipore

规格：

目录价：￥3982.00

市场价格：￥3384.70

会员价格：￥3185.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TFPI-2 Antibody | ABT27 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes TFPI-2. View All» Molecular Weight: The additional molecular weight bands appear to correspond to 3 differentially glycosylated forms of TFPI-2 as described in publication (Iino, 1998). View All» Epitope: Unknown View All» Immunogen: Recombinant protein corresponding to human TFPI-2. View All» Isotype: IgG View All» Background Information: Tissue factor pathway inhibitor-2 (TFPI-2), a structural homologue of TFPI, is a Kunitz-type serine proteinase inhibitor having high expression in the extracellular matrix of fibroblasts, endothelial cells, keratinocytes, synoviocytes, and smooth muscle cells. The protein consists of three, repeating Kunitz-type domain structures with a basic amino acid enriched C-terminal tail, and an acidic amino acid N-terminal region. The C-terminal tail of TFPI-2 is necessary to the protein’s transduction through the cell-membrane and into the nucleus. Studies have shown TFPI-2 to inhibit chymotrypsin, plasmin, cathepsin G, trypsin, and plasma kallikrein. Various lines of research have suggested an inverse relationship between TFPI-2 expression and the malignancy of invasive cell lines such as gliomas and to have a role in cancer invasion, progression, and metastasis. It has also been suggested that TFPI-2 induces caspase-mediatedapoptosis when offered to a variety of tumor cells (Kempaiah, 2009). TFPI-2 expression has been observed in full-term placenta, along with several adult tissue types such as kidney, liver, heart, skeletal muscle, and pancreas. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other noted sequence homologies include Rat (55%) and Mouse (54%). View All» Application Notes: Immunofluorescence: An independent laboratory has shown the use of the TFPI-2 antibody by immunofluorescent staining (Kempaiah, 2009).Immunohistochemistry: An independent laboratory has shown the use of the TFPI-2 antibody by immunohistochemical staining (Chand, 2004). View All» Control: Human placenta tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human placenta tissue lysate.Western Blot Analysis: 1:1,000 dilution of the antibody detected TFPI-2 in 10 µg of human placenta tissue lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing Tris-HCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P48307 View All» Entrez Gene Number: NP_006519 View All» Gene Symbol:

• PP5

• TFPI-2

• REF1
  View All» Alternate Names:
  • Tissue factor pathway inhibitor 2

  • Placental protein 5
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICTY: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.DOMAIN: This inhibitor contains three inhibitory domains.SEQUENCE SIMLARITIES: Contains 3 BPTI/Kunitz inhibitor domains. View All» Product Name: Anti-TFPI-2 View All» Concentration: 5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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