货号：ABT20

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Atlastin-3 Antibody | ABT20 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes Atlastin-3. View All» Molecular Weight: ~ 55 - 60 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse Atlastin-3. View All» Isotype: IgG View All» Background Information: Atlastin is a recently characterized, integral protein GTPase similar to members of the dynamin family of large GTPases. It is primarily localized on the Golgi apparatus and regularly considered to contain two transmembrane domains which result in the exposure of both the N-terminal and C-terminal ends to the cytoplasm. Studies have shown atlastin to bind with spastin in biological pathways, such as microtubule-severing leading to axon outgrowth. Mutations in atlastin expression are causal to childhood onset HSP, a group of conditions in which spastic parapalegia occurs. Atlastin has been found in several tissues throughout the body. The most significant levels of atlastin have been observed in the brain and spinal cord. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react in human, mouse, and rat. View All» Application Notes: Western Blot Analysis: 1;1000 dilution from a previous lot detected Atlastin-3 on 10 µg of C2C12, L6, mouse brain, NIH/3T3, and RAW264.7 lysates. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1;1000 dilution of this antibody detected Atlastin-3 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q91YH5 View All» Entrez Gene Number: NP_666203.3 View All» Gene Symbol:
  • atlastin 3

  • ATL3
    View All» Alternate Names: atlastin GTPase 3 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis by similarity.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein by similarity. SEQUENCE SIMILARITIES: Belongs to the GBP family. Atlastin subfamily. View All» Product Name: Anti-Atlastin-3 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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