货号：ABT177

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TPX2 Antibody | ABT177 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~100 kDa observed. The calculated molecular weight of this protein is 83 kDa; however, it has been observed at ~100 kDa in some cell lysates (Gruss, O. J. et al. (2002). Nat Cell Biol. 4(11);871-879.). View All» Immunogen: Recombinant protein corresponding to human TPX2. View All» Background Information: Targeting protein for Xklp2 (TPX2) is a microtubule formation and bundling protein that activates Ser/Thr kinase Aurora A during mitosis and targets it to the mitotic spindle. This effect on Aurora A, along with microtubule nucleation, is mediated by the N-terminus and C-terminus of TPX2, respectively. TPX2 is also required for normal assembly of microtubules during apoptosis. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated TPX2 from Xenopus M phase extract (Gruss, O. J., et al. (2001). Cell. 104(1):83-93.). This publication used a purified form of this antibody when performing the IP. Cat. No. ABT177 is an unpurifed form of this antibody.Immunocytochemistry Analysis: A representative lot from an independent laboratory detected TPX2 in a time-dependent assay using HeLa cells arrested in S phase (Gruss, O. J. et al. (2002). Nat Cell Biol. 4(11);871-879.). This publication used a purified form of this antibody when performing the ICC. Cat. No. ABT177 is an unpurifed form of this antibody. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: A 1:1,000 dilution from a representative lot detected TPX2 in 10 µg of HepG2 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9ULW0 View All» Entrez Gene Number: NP_036244 View All» Gene Symbol:

• TPX2

• C20orf1

• C20orf2

• DIL2

• HCA519
  View All» Alternate Names:
  • Targeting protein for Xklp2

  • Differentially expressed in cancerous and non-cancerous lung cells 2

  • DIL-2

  • Hepatocellular carcinoma-associated antigen 519

  • Protein fls353

  • Restricted expression proliferation-associated protein 100

  • p100
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation

    • Immunocytochemistry
      View All» Product Name: Anti-TPX2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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