货号：ABT138

品牌：Merck Millipore

规格：

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Stabilin-2 Antibody | ABT138 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the cytoplasmic domain of Stabilin-2. View All» Molecular Weight: ~315 and ~190 kDa observed. Uncharacterized bands may appear at ~18 kDa, ~48 kDa, and ~59 kDa in some lysates. Like human spleen sinusoidal endothelial cells, Flp-In 293 cell lines transfected with a single cDNA encoding the full-length 315-HARE express both the 315-kDa and the proteolytically truncated 190-kDa isoforms in a ratio of 3–4:1. (Harris, E.N., et al. (2007). The Journal of Biological Chemistry. 282(5):2785-2797.) View All» Epitope: Cytoplasmic domain View All» Immunogen: GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Stabilin-2. View All» Background Information: Stabilin-2 (Stab2; FEEL-2; and HARE) is a phosphatidylserine receptor that is localized to hepatic sinusoidal endothelial cells. It is a large protein containing a linker domain, two laminin EGF-like domains, four FAS1 domains, and six EGF-like domains, enabling stabilin-2 to perform multiple functions. Stabilin-2 is primarily studied for its role as a scavenger receptor that is involved in the clearance of metabolic waste products, which may include hyaluronic acid, heparin, advanced glycation end-products, acetylated LDL, and chondroitin sulfates. Previous studies have also suggested that stabilin-2 may play a role in cell adhesion processes. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Human spleen tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human spleen tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Stabilin-2 in 10 µg of human spleen tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8WWQ8 View All» Entrez Gene Number: NP_060034 View All» Gene Symbol:

• STAB2

• FEEL2

• FELL

• FEX2

• HARE
  View All» Alternate Names:
  • Stabilin-2

  • FAS1 EGF-like and X-link domain-containing adhesion molecule 2

  • Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 2

  • FEEL-2

  • Hyaluronan receptor for endocytosis
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-Stabilin-2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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