货号：ABT132

品牌：Merck Millipore

规格：

目录价：￥4316.00

市场价格：￥3668.60

会员价格：￥3452.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Profilin-1 Antibody | ABT132 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~15 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Profilin-1. View All» Background Information: Profilin-1 (PFN1) is a small cytoplasmic protein that regulates actin polymerization in response to various extracellular signals. It may bind G-actin preventing actin assembly, which is released upon stimulation with phosphatidylinositol 4,5-bisphosphate. At low concentrations, Profilin-1 may also facilitate nucleotide exchange required for elongation of actin filaments. Profilin-1 also interacts with polyproline-containing proteins, such as the Huntingtin protein, to inhibit protein aggregation. Profilin-1 is regulated by phosphorylation of its Ser137 residue by ROCK, and dephosphorylation by the protein phosphatase 1. In normal cells, Profilin-1 may be involved in cell adhesion, cytokinesis, cell motility, vesicle formation, and neuron migration. It is also associated with neurodegenerative diseases and cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Canine, Hamster, Rhesus Macaque, Giant Panda, and Chimpanzee based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a representative lot detected Profilin-1 in 10 µg of Jurkat and C2C12 cell lysates, rat kidney and human kidney tissue lysates.Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Profilin-1 in HeLa, C2C12, and A431 cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Profilin-1 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein A purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07737 View All» Entrez Gene Number: NP_005013 View All» Gene Symbol: PFN1 View All» Alternate Names:
  • Profilin-1

  • Profilin 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Product Name: Anti-Profilin-1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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