货号：ABT121

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-T-cadherin (CDH13) Antibody | ABT121 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes T-cadherin at the Cadherin 1 domain. This antibody detects the ~130 kDa pro-protein and the proteolytically cleaved ~105 kDa mature isoforms. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.) View All» Molecular Weight: ~130 and ~105 kDa observed. ~130 kDa corresponds to the pro-protein and ~105 kDa corresponds to the proteolytically cleaved mature isoform. (Denzel, M., et al. (2010). J Clin Invest.120(12):4342–4352.) View All» Epitope: Cadherin 1 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human T-cadherin at the Cadherin 1 domain. View All» Background Information: T-cadherin (CDH13), also known as Cadherin 13, is a member of the cadherin superfamily. This protein is unique from its other family members in that it lacks the cytoplasmic domains and is anchored to the cells membrane through the GPI anchor. T-cadherin is widely expressed in the cardiovascular system. Mutations in T-cadherin have been associated with many types of cancer. View All» Species Reactivity:

• Human

• Rat

• Bovine

• Horse

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Bovine, Equine, and Mouse based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected T-cadherin in human brain and human heart tissues. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human heart tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected T-cadherin on 10 µg of human heart tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55290 View All» Entrez Gene Number: NP_001248 View All» Gene Symbol:
  • CDH13

  • CDHH
    View All» Alternate Names:
    • Cadherin-13

    • Heart cadherin

    • H-cadherin

    • P105

    • Truncated cadherin

    • T-cad

    • T-cadherin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]. View All» UniProt Summary: FUNCTION: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor › GPI-anchor TISSUE SPECIFICITY: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. DEVELOPMENTAL STAGE: Expressed at higher levels in adult brain than in developing brain. SEQUENCE SIMILARITIES: Contains 5 cadherin domains. View All» Product Name: Anti-T-cadherin (CDH13) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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