货号：ABT11

品牌：Merck Millipore

规格：100Ug

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fibroblast activation protein alpha (FAP) Antibody | ABT11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes the extracellular domain of Fibroblast activation protein alpha View All» Molecular Weight: ~ 90 kDa observed MW. Two isoforms of the Fibroblast activation protein exist at calculated MWs of 88kDa and 27 kDa. It is possible that both bands may be obserbved in certain cell lines. View All» Epitope: Extracellular domain View All» Immunogen: Histidine-tagged recombinant protein corresponding to human FAP. View All» Isotype: IgG View All» Background Information: Fibroblast activation protein alpha (FAP), also known as Seprase, is a 97 kDa, type II cell surface glycoprotein belonging to the serine protease family. Although FAP is considered fibroblast specific, it is not found in normal healthy fibroblasts. FAP is most commonly found in stromal, tumor fibroblasts, and is likely involved in ECM pericellular proteolysis, endothelial cell migration and invasion into the ECM. The presence of FAP in human epithelial carcinoma is increased, particularly in breast, colorectal, lung, and ovarian carcinomas. FAP is also transiently observed in developing cells, or in tissues that are undergoing wound healing or suffering from chronic inflammatory conditions. Due to its specific distribution both to tumor fibroblasts and to inflammed tissue, FAP makes a promising target for research in tumor-stromal studies and in therapeutic studies. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunohistochemistry: A 1:750 dilution of a previous lot of FAP antibody was used to immunohistochemically stain frozen tissue sections of HEK-FAP or HT-29 xenograft tumors from C.B17 mice (Cheng, 2002).Inhibition: Inhibition of dipeptidyl peptidase activity with a previous lot of FAP antibody on HT-29 xenograft tumors was demonstrated by an independent laboratory (Cheng, 2002). View All» Control: HEK-FAP xenograft tumor lysate View All» Quality Assurance: Evaluated by Western Blot in HEK-FAP xenograft tumor lysate.Western Blot Analysis: 2.5 µg/mL of this antibody detected FAP in 10 µg of HEK-FAP xenograft tumor lysate. View All» Purification Method: Ammonium Sulfate View All» Presentation: Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q12884 View All» Entrez Gene Number: NP_004451 View All» Gene Symbol:

• FAPA

• FAP

• DPPIV
  View All» Alternate Names:
  • fibroblast activation protein, alpha

  • fibroblast activation protein, alpha subunit

  • integral membrane serine protease

  • seprase

  • 170 kDa melanoma membrane-bound gelatinase, FAP
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry

    • Affects Function
      View All» Entrez Gene Summary: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. CATALYTIC ACTIVITY: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.SUBUNIT STRUCTURE: Homodimer, or heterodimer with DPP4. The monomer is inactive. SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Cell projection › lamellipodium membrane; Single-pass type II membrane protein. Cell projection › invadopodium membrane; Single-pass type II membrane protein. Note: Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. TISSUE SPECIFICTY: Fibroblast specific.INDUCTION: In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and carcinogenesis.PTM: N-glycosylated. Ref.11 Ref.9The N-terminus may be blocked.SEQUENCE SIMILARITIES: Belongs to the peptidase S9B family. View All» Product Name: Anti-Fibroblast activation protein alpha (FAP) View All» Concentration: 2.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-159629.htm
      © Merck Millipore代理ABT11 Anti-Fibroblast activation protein alpha (FAP) Antibody;抗成纤维细胞活化蛋白α（FAP）抗体store at +2℃ to +8℃，产品报价联系微信jinshanbio