货号：ABS82

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VEGF Antibody | ABS82 View All» Replaces: 07-1376 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes VEGF at the N-terminus. View All» Molecular Weight: ~ 55 kDa observed. UniProtKB/Swiss-Prot P15692 (VEGFA_HUMAN) entry describes 13 isoforms produced by alternative promoter usage, alternative splicing and alternative initiation: Isoform 1 at 27.042 kDa, Isoform 2 at 25.173 kDa, Isoform 3 at 24.422 kDa, Isoform 4 at 22.314 kDa, Isoform 5 at 20.218 kDa, Isoform 6 at 20.064 kDa, Isoform 7 at 22.259 kDa, Isoform 8 at 17.219 kDa, Isoform 9 at 15.981 kDa, Isoform 10 at 40.738 kDa, Isoform 11 at 35.643 kDa, Isoform 12 at 43.597 kDa, Isoform 13 at 45.467 kDa. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human VEGF at the N-terminus. View All» Background Information: VEGF (Vascular endothelial growth factor, VEGFA, VEGF-A), a dimeric ligand, is among the most potent angiogenic mitogens. VEGF is secreted by tumor cells and other cells exposed to hypoxia. VEGF is a highly specific mitogen for vascular endothelial cells. Seven VEGF isoforms (a, b, c, d, e, f, g) are generated as a result of alternative splicing from a single VEGF gene. The most commonly studied isoforms are VEGF121, VEGF165, and VEGF189 (f, d and b, respectively) All seven isoforms differ in their molecular mass and in biological properties such as their ability to bind to cell-surface heparan-sulfate proteoglycans. The expression of VEGF is potentiated and is secreted by tumor cells in response to hypoxia, by activated oncogenes, and by a variety of cytokines. VEGF induces angiogenesis as well as permeabilization of blood vessels, and plays a central role in the regulation of vasculogenesis. VEGF expression correlates to the degree of tumor vascularization and with increased metastatic risk. Additionally, VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis. Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Primate
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with primate based on 100% sequence homology. Other homologies: Bovine (85% sequence homology). Rat (70% sequence homology). Mouse (65% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: 1:400 dilution from a previous lot detected VEGF in normal human placental villi tissue. View All» Control: HuVec cell lysate View All» Quality Assurance: Evaluated by Western Blot in HuVec cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected VEGF on 10 µg of HuVec cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15692 View All» Entrez Gene Number: NP_001020537 View All» Gene Symbol:
  • VPF

  • VEGF-A

  • MVCD

  • VEGF

  • VEGA
    View All» Alternate Names:
    • vascular endothelial growth factor A

    • vascular endothelial growth factor

    • Vascular permeability factor

    • vascular endothelial growth factor isoform VEGF
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Binds to the VEGFR1/Flt-1 and VEGFR2/Kdr receptors, heparan sulfate and heparin. Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. SUBUNIT: Homodimer; disulfide-linked. Also found as heterodimer with PlGF (By similarity). SUBCELLULAR LOCATION: Secreted. Note=VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a signicant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin. ALTERNATIVE PRODUCTS: 10 named isoforms [FASTA] produced by alternative splicing. View All» Product Name: Anti-VEGF View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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