货号：ABS70

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Toca-1 Antibody | ABS70 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 62 kDa observed. View All» Immunogen: Linear peptide corresponding to human Toca-1. View All» Background Information: Transducer of Cdc42-dependent actin assembly (Toca-1) belongs to the Formin-binding protein 1 (FNBP1) family. This protein binds Cdc42 and Neural Wiskott-Aldrich syndrome protein (N-WASP) by promoting actin polymerization through the N-WASP complex. Toca-1 is highly expressed in neurons, including neurons of the hippocampus, in developing brains. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Western Blot Analysis: 2 µg/mL of this antibody detected Toca-1 on 10 µg of RAW264.7 cell lysate. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected Toca-1 on 10 µg of PC3 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q5T0N5 View All» Entrez Gene Number: NP_060207 View All» Gene Symbol:
  • FBP17

  • hFBP17

  • Toca-1
    View All» Alternate Names:
    • formin binding protein 1

    • Formin-binding protein 17

    • Transducer of Cdc42-dependent actin assembly protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. SUBUNIT STRUCTURE: Interacts with GTP-bound CDC42. Interacts with DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 and WASL/N-WASP. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton (By similarity). Cytoplasm › cell cortex (By similarity). Cytoplasmic vesicle (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). SEQUENCE SIMILARITIES: Belongs to the FNBP1 family.Contains 1 FCH domain.Contains 1 REM (Hr1) repeat.Contains 1 SH3 domain.SEQUENCE CAUTION: The sequence BAA91051.1 differs from that shown. Reason: Erroneous initiation. The sequence CAI18954.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAI18981.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-Toca-1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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