货号：ABS65

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CPT1A Antibody | ABS65 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~78 kDa observed. An uncharacterized band appears at ~32 kDa in some lysates. The calculated molecular weight is 88 kDa, however CPT1A has been shown as a ~78 kDa band in western blots (Tan, L., et al (2011). J Inherit Metab Dis. 34:443–447.) View All» Immunogen: GST-tagged recombinant protein corresponding to rat CPT1A. View All» Isotype: IgG View All» Background Information: Carnitine palmitoyltransferase 1A (CPT1A, CPT1-L, or L-CPT1) is an hepatic enzyme that, together with CPT2 and carnitine-acylcarnitine translocase, mediates the oxidation of long chain fatty acids to produce energy, in periods of fasting. CPT1A is localized in the outer mitochondrial membrane and catalyzes the addition of carnitine to long-chain fatty acids thereby enabling effective transport of these molecules to the inner mitochondrial membrane where they are metabolized. CPT1A may function as part of a complex consisting of the acyl-CoA synthetase (ACSL) and the voltage-dependent anion channel (VDAC) and is regulated by malonyl-CoA. Deficiencies in CPT1A result in hypoketotic hypoglycemia. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. View All» Control: Mouse liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse liver tissue lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected CPT1A on 10 µg of mouse liver tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P50416 View All» Entrez Gene Number: NP_001867 View All» Gene Symbol:
  • CPT1A

  • CPT1
    View All» Alternate Names:
    • Carnitine O-palmitoyltransferase 1, liver isoform

    • CPT1-L

    • Carnitine O-palmitoyltransferase I, liver isoform

    • CPT I

    • CPTI-L

    • Carnitine palmitoyltransferase 1A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: CATALYTIC ACTIVITY: Palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.ENZYME REGULATION: Inhibitors such as malonyl-CoA interact with its catalytic domain and not with an associated regulatory component.PATHWAY: Lipid metabolism; fatty acid beta-oxidation.SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strong expression in kidney and heart, and lower in liver and skeletal muscle.INVOLVEMENT IN DISEASE: Defects in CPT1A are the cause of carnitine palmitoyltransferase 1A deficiency (CPT1AD) [MIM:255120]; also known as CPT-I deficiency or CPT1A deficiency. CPT1AD is a rare autosomal recessive metabolic disorder of long-chain fatty acid oxidation characterized by severe episodes of hypoketotic hypoglycemia usually occurring after fasting or illness. Onset is in infancy or early childhood. SEQUENCE SIMILARITIESl Belongs to the carnitine/choline acetyltransferase family. View All» Product Name: Anti-CPT1A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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