货号：ABS53

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FHOD1 Antibody | ABS53 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FHOD1 at the N-terminus. View All» Molecular Weight: ~ 130 kDa observed View All» Epitope: N-terminus View All» Immunogen: Linear peptide corresponding to human FHOD1 at the N-terminus. View All» Background Information: Formin-homology-2-domain containing protein 1 (FHOD1) is a member of the forming homology (FH) family, a group of proteins that act to regulate several cellular processes such as; embryonic patterning, cell survival, cytoskeletal organization, gene transcription and migration. FH proteins are able to regulate these processes through their interaction with actin binding proteins and by serving to bridge Rho-family GTPases with Src tyrosine kinase and the pathway for Wnt Signaling. As a member of the FH family, FHOD1 contains several characteristic domains including; a GTPase Binding Domain (GBD, a coiled coil, FH1 and FH2 domains, and a Diaphanous-like autoregulatory domain (DAD). FHOD1 is a necessary component in F-actin structure assembly and its activity is dependant on the RHO-Rock. Expression of FHOD1 is ubiquitous, but is highest in the spleen. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Western Blot Analysis: 2 µg/mL of this antibody detected FHOD1 on 10 µg of HeLa cell lysate. View All» Control: Huvec cell lysate View All» Quality Assurance: Evaluated by Western Blot in Huvec cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected FHOD1 on 10 µg of Huvec cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y613 View All» Entrez Gene Number: NP_037373 View All» Gene Symbol: FHOD1 View All» Alternate Names:

• formin homology 2 domain containing 1

• FHOS

• FH1/FH2 domain-containing protein

• FHOS1

• Formin homology 2 domain-containing protein 1

• Formin homolog overexpressed in spleen 1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. SUBUNIT STRUCTURE: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton. Note: Predominantly cytoplasmic. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen.DOMAIN: Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein.SEQUENCE SIMILARITIES: Belongs to the formin homology family.Contains 1 FH1 (formin homology 1) domain.Contains 1 FH2 (formin homology 2) domain.Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. View All» Product Name: Anti-FHOD1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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