货号：ABS40

品牌：Merck Millipore

规格：

目录价：￥4167.00

市场价格：￥3541.95

会员价格：￥3333.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PTP-1B Antibody | ABS40 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 50 kDa observed View All» Epitope: 0 View All» Immunogen: Recombinant protein corresponding to mouse PTP-1B. View All» Background Information: PTP-1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP-1B is a negative regulator of insulin and leptin signal transduction and is a drug discovery target in the fields of diabetes and obesity. Insulin also influences the expression of splice variants of PTP-1B. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. View All» Control: NIH/3T3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected PTP-1B on 10 µg of NIH/3T3 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35821 View All» Entrez Gene Number: NP_035331 View All» Gene Symbol:
  • PTP-1B

  • PTP1B
    View All» Alternate Names:
    • Protein-tyrosine phosphatase 1B

    • protein tyrosine phosphatase 1B

    • protein tyrosine phosphatase, non-receptor type 1

    • protein tyrosine phosphatase, placental
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: May play an important role in CKII- and p60c-src-induced signal transduction cascades (By similarity).CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). TISSUE SPECIFICITY: Most abundant in testis. Also found in kidney, spleen, muscle, liver, heart and brain.SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.Contains 1 tyrosine-protein phosphatase domain. View All» Product Name: Anti-PTP-1B View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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