货号：ABS31

品牌：Merck Millipore

规格：

目录价：￥4884.00

市场价格：￥4151.40

会员价格：￥3907.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-2A Peptide Antibody | ABS31 View All» Replaces: ABS31 is a direct replacement for 09-085 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: Recognizes the 2A sequence, derived from Foot and Mouth picornavirus (VKQTLNFDLLKLAGDVESNPG*P), where * represents the 2A cleavage site. The epitope is believed to be within the “GDVEENPG” region since the antibody also recognizes the unrelated 2A regions from Thosea asigna virus and Equine rhinitis A virus. View All» Molecular Weight: varies View All» Epitope: The epitope is believed to be within the “GDVEENPG” region. View All» Immunogen: The immunogen used was recombinant 2A from foot and mouth virus1. View All» Background Information: 2A peptides and 2A-like peptide sequences (also known as CHYSEL, or cis-acting hydrolase elements) are a superior alternative to internal ribosomal entry sites (IRES) for coordinating the expression of multiple gene products from a single recombinant construct. 2A peptides allow multiple proteins to be encoded as polyproteins, which then dissociate into component proteins upon translation. The 2A sequence impairs normal peptide bond formation via a mechanism called ribosomal skipping, resulting in effective, non-enzymatic generation of distinct peptide products from a single multicistronic construct. The use of 2A sequences allows the stoichiometric production of up to four proteins from a single vector, making it a powerful tool for the equimolar expression of multiple cistrons. View All» Control: 2A-containing recombinant proteins View All» Quality Assurance: Western Blot Analysis: A multicistronic vector was synthesized consisting of several CD3 proteins linked with 2A peptide sequences from foot and mouth disease, Thosea asigna, and Equine rhinitis A viruses, respectively (CD3δ-F2A-CD3ε-T2A-CD3γ-E2A-CD3ζ)1. The vector was transduced in 293 cells. A 1:1000 dilution of this antibody detected the 2A sequence in all three CD3-2A proteins (CD3 epsilon, gamma, delta) generated from a single 2A peptide-linked retroviral vector. View All» Presentation: Serum with 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P05204 View All» Entrez Gene Number: NP_005508 View All» Gene Symbol:

• HMG17

• MGC5629

• MGC88718

• OTTHUMP00000003669
  View All» Alternate Names:
  • High-mobility group nucleosome-binding domain-containing protein 2

  • high mobility group protein N2

  • high-mobility group (nonhistone chromosomal) protein 17

  • high-mobility group nucleosomal binding domain 2

  • nonhistone chromosomal protein HMG-17
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation By similarity.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note= Cytoplasmic enrichment upon phosphorylation. Ref.7PTM: Phosphorylation favors cytoplasmic localization.SEQUENCE SIMILARITY: Belongs to the HMGN family.MOLECULAR WEIGHT: Mass spectrometry Molecular weight is 9261.5 Da from positions 2 - 90. Determined by ESI. Ref.7Molecular weight is 9341.3±1.9 Da from positions 2 - 90. Determined by ESI. Ref.7Molecular weight is 9421.5 Da from positions 2 - 90. Determined by ESI. Ref.7 View All» Product Name: Anti-2A Peptide View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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