货号：ABS227

品牌：Merck Millipore

规格：50Ug

目录价：￥3724.00

市场价格：￥3165.40

会员价格：￥2979.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FKBP5 Antibody | ABS227 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~56 kDa observed. An uncharacterized band at ~15 kDa may be observed in some cell lysates. View All» Immunogen: KLH-conjugated linear peptide corresponding to human FKBP5. View All» Background Information: FK506 binding protein 51 (FKBP5) is a ubiquitous immunophilin, which has been implicated in multiple mood disorders such as depression, anxiety, and post-traumatic stress disorder, through its regulation of multiple enzymes, transcription factors, and other signaling molecules. It is also a well known co-chaperone of the Hsp90 protein, which regulates the signaling of the glucocorticoid receptor (GR), by a negative feedback mechanism. The expression of FKBP5 increases with rising glucocorticoid levels, and FKBP5 in turn decreases GR signaling by promoting nuclear translocation of GR isoforms. In contrast, FKBP5 functions as a positive regulator of the androgen receptor. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Bovine based on 100% sequence homology. Other homologies: Rat (92% sequence homology). View All» Application Notes: Western Blot Analysis: 0.05 µg/mL of this antibody detected FKBP5 in 10 mg of K562 cell lysate. View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 0.05 mg/mL of this antibody detected FKBP5 in 10 mg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13451 View All» Entrez Gene Number: NP_004108 View All» Gene Symbol:

• FKBP5

• AIG6

• FKBP51
  View All» Alternate Names:
  • Peptidyl-prolyl cis-trans isomerase FKBP5

  • Peptidyl-prolyl cis-trans isomerase FKBP5

  • 51 kDa FK506-binding protein

  • 51 kDa FKBP

  • FKBP-51

  • 54 kDa progesterone receptor-associated immunophilin

  • Androgen-regulated protein 6

  • FF1 antigen

  • FK506-binding protein 5

  • FKBP-5

  • FKBP54

  • p54

  • HSP90-binding immunophilin

  • Rotamase
    View All» Key Applications: Western Blotting View All» Product Name: Anti-FKBP5 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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