货号：ABS225

品牌：Merck Millipore

规格：EA

目录价：￥2976.00

市场价格：￥2529.60

会员价格：￥2380.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CASK Antibody | ABS225 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the Guanylate kinase-like region of CASK. View All» Molecular Weight: ~112 kDa observed. Uniprot describes 6 isoforms produced by alternative splicing at ~105 kDa, ~102 kDa, ~59 kDa, and ~103 kDa. View All» Immunogen: KLH-conjugated linear peptide corresponding to the Guanylate kinase-like region of human CASK. View All» Background Information: CASK (calcium/calmodulin-dependent serine protein kinase) belongs to the protein kinase super family; CAMK Ser/Thr protein kinase family; CaMK subfamily; and the membrane-associated guanylate kinase (MAGUK) family. MAGUKs are defined by a tripartite domain structure: a Src homology 3 (SH3) domain, a domain with homology to the enzyme guanylate kinase (GUK), and a PDZ domain. CASK may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and protein 4.1. Like other MAGUKs, its multidomain structure enables it to act as a scaffold at the membrane, potentially recruiting multiple proteins and coordinating signal transduction. Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK) [MIM: 300749]. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Patients with mental retardation X-linked CASK-related can manifest a severe phenotype consisting of severe intellectual deficit, congenital or postnatal microcephaly, disproportionate brainstem and cerebellar hypoplasia (MICPCH Syndrome). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse and Rat. Predicted to react with Bovine and Canine based on 100% sequence homology. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected CASK in 10 µg of mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O14936 View All» Entrez Gene Number: NP_001119527 View All» Gene Symbol:
  • CASK

  • LIN2
    View All» Alternate Names:
    • Peripheral plasma membrane protein CASK

    • Hcask

    • Calcium/calmodulin-dependent serine protein kinase

    • Protein lin-2 homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-CASK View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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