货号：ABS205

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-STK33 Antibody | ABS205 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~58 kDa observed. 2 isoforms are produced by alternative splicing: 57 kDa (Isoform 1) and 50 kDa (Isoform 2). Uncharacterized bands at ~70 kDa and ~16 kDa may be observed in some cell lysates. View All» Epitope: 0 View All» Immunogen: Histidine-tagged recombinant protein corresponding to human STK33. View All» Background Information: STK33 is a serine/threonine protein kinase that promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of BAD. It is selectively required for the survival and proliferation of mutant KRAS-dependent cancer cells across a wide range of tissue contexts. STK33 is expressed in low amounts in most tissues; however, it is highly expressed in testis, particularly in cells from the spermatogenic epithelia. Moreover, significant expression is found in alveolar macrophages, lung epithelia, horizontal cells in the retina, and in embryonic organs such as brain, heart, and spinal cord. STK33 is suggested to play a role in spermatogenesis and organ ontogenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Application Notes: Immunohistochemistry (Paraffin) Analysis: A previous lot of this antibody was used to detect STK33 in the seminiferous tubule epethelium of rat testis.Multiplex Assay: A previous lot of this antibody was used in Multiplex Assays. View All» Control: Human heart tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human heart tissue lysate.Western Blot Analysis: A 1:250 dilution of this antibody detected STK33 in 10 µg of human heart tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9BYT3 View All» Entrez Gene Number: NP_112168 View All» Gene Symbol: STK33 View All» Alternate Names: Serine/threonine-protein kinase 33 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Multiplexing

  • Immunohistochemistry (Paraffin)
    View All» UniProt Summary: CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBCELLULAR LOCATION: Cytoplasm > perinuclear region.TISSUE SPECIFICITY: Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophagus, colon ascending, colon transverse, skeletal muscle, spleen, peripheral blood leukocyte, lymph node, bone marrow, placenta, prostate, liver, salivary gland, mammary gland, some tumor cell lines, fetal brain, fetal liver, fetal spleen and fetal thymus. No signal at all was detectable in RNA from tissues of the nervous system. View All» Product Name: Anti-STK33 Antibody | ABS205 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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