货号：ABS180

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDE4B1 Antibody | ABS180 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PDE4B1 near the N-terminus. View All» Molecular Weight: ~104 kDa observed. UniProtKB describes 3 isoforms produced by alternative splicing: 83, 64, and 82 kDa. PDE4B1 and PDE4B3 isoforms have a molecular mass approximately 20 kDa larger based on their mobility in SDS-PAGE. (Huston, E., et al. (1997). Biochem. J. 328:549-558.) View All» Epitope: Near N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human PDE4B1 near the N-terminus. View All» Background Information: Phosphodiesterase 4B1 (PDE4B1) is a member of the PDE cyclic nucleotides. PDE4B1 is thought to contain both UCR1 and UCR2 regulatory units. PDE4B1 has been associated with schizophrenia and depression and could be a promising target for autism therapies.PDE4B1 created a doublet with PDE4B3, which increases in the presence of high levels of cAMP. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with Mouse. Expected to react with human based on immunogen design. View All» Control: Mouse brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in Mouse brain tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected PDE4B1 on 10 µg of Mouse brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q07343 View All» Entrez Gene Number: NP_001032418 View All» Gene Symbol:

• PDE4B

• DPDE4
  View All» Alternate Names:
  • cAMP-specific 3',5'-cyclic phosphodiesterase 4B

  • DPDE4

  • PDE32
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. CATALYTIC ACTIVITY: Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. ENZYME REGULATION: Inhibited by rolipram.PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.TISSUE SPECIFICITY: Expressed in brain, heart, lung and skeletal muscle.SEQUENCE SIMILARITIES: Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. View All» Product Name: Anti-PDE4B1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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