货号：ABS17

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Apolipoprotein C-III Antibody | ABS17 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-Terminus of Apolipoprotein C-III. Cross reactivity to Apolipoprotein B determined by ELISA. View All» Molecular Weight: ~14 kDa observed. 11 kDa calculated. In Western Blot Apo CIII monomer runs ~ 8.75kDa, however unless strong denaturing reagents such as 5M guanidine-HCL are used, aggregates of Apo CIII are common resulting in significant larger bands or smears. View All» Epitope: N-Terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-Terminus of human Apolipoprotein C-III. View All» Background Information: Apolipoprotein C-III (ApoC-III) has been shown to be an essential part of the metabolism of triglyceride-rich lipoproteins. ApoC-III is thought to exist in three different isoforms (ApoC-III0, ApoC-III1, and ApoC-III2) based on the sialylation degree. The primary CIII1 and CIII2 isoforms, contribute to hypertriglyceridemia and that apoC-III2 may be important in the expression of the small, dense LDL phenotype. Regulating apoC-III metabolism could be a promising new therapeutic approach to managing dyslipidaemia and cardiovascular disease risk in the metabolic syndrome. ApoC-III has been found to be over-expressed in patients with uremia. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected Apolipoprotein C-III in normal human liver. View All» Control: Normal human sera View All» Quality Assurance: Evaluated by Western Blot in normal human sera.Western Blot Analysis: 0.1 µg/mL of this antibody detected Apolipoprotein C-III on 10 µg of normal human sera. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P02656 View All» Entrez Gene Number: NP_000031 View All» Gene Symbol: APOC3 View All» Alternate Names:
  • Apolipoprotein C-III

  • Apo-CIII

  • ApoC-III

  • Apolipoprotein C3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: Summary: Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.POST-TRANSLATIONAL MODIFICATION: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.INVOLVEMENT IN DISEASE: Defects in APOC3 may be a cause of hyperalphalipoproteinemia (HYPALIP) [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).SEQUENCE SIMILARITIES: Belongs to the apolipoprotein C3 family. View All» Product Name: Anti-Apolipoprotein C-III View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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