Merck Millipore代理ABS14 Anti-PKA RII Beta Antibody;store at +2℃ to +8℃

2025-07-05

货号:ABS14

品牌:Merck Millipore

规格:100Ug

目录价:¥4438.00

市场价格:¥3772.30

会员价格:¥3550.40

金山科研平台,产品价格货期咨询微信:jinshanbio Description: Anti-PKA RII Beta Antibody | ABS14 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PKA RII Beta at the cAMP2 domain. View All» Molecular Weight: ~ 46 kDa observed View All» Epitope: cAMP2 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human PKA RII Beta at the cAMP2 domain. View All» Background Information: PKA RII Beta is a type two regulatory chain which mediates membrane association by binding to anchoring proteins, including the MAP2 kinase. When the enzyme is inactive there are two regulatory chains and two catalytic chains. PKA RII Beta is activated by cAMP and produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. View All» Species Reactivity:

  • Human

  • Mouse

  • Rhesus Macaque

  • Horse

  • Chimpanzee

  • Canine

  • Bovine

    View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rhesus macaque, equine, chimpanzee, canine, and bovine based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 0.5 µg/mL from a previous lot detected PKA RII Beta on 10 µg of mouse brain tissue lysate. View All» Control: Human brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human brain tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected PKA RII Beta on 10 µg of human brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P31323 View All» Entrez Gene Number: NP_002727 View All» Gene Symbol:
    • PRKAR2

    • PRKAR2B

    • RII-BETA

      View All» Alternate Names:
      • protein kinase, cAMP-dependent, regulatory, type II, beta

      • cAMP-dependent protein kinase type II-beta regulatory chain

      • cAMP-dependent protein kinase type II-beta regulatory subunit

        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SUBUNIT STRUCTURE: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules.TISSUE SPECIFICITY: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM: Phosphorylated by the activated catalytic chain. Ref.5 Ref.6 Ref.8 Ref.9SEQUENCE SIMILARITIES: Belongs to the cAMP-dependent kinase regulatory chain family.Contains 2 cyclic nucleotide-binding domains. View All» Product Name: Anti-PKA RII Beta View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»

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