货号：ABN88

品牌：Merck Millipore

规格：100Ug

目录价：￥6322.00

市场价格：￥5373.70

会员价格：￥5057.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-NR1 (Ser896) Antibody | ABN88 View All» Replaces: 06-640 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NR1 when phosphorylated at Ser896. View All» Molecular Weight: ~130kDa observed View All» Epitope: Phosphorylated Ser896 View All» Immunogen: KLH-conjugated linear peptide corresponding to rat NR1 phosphorylated at Ser896. View All» Modifications: Phosphorylation View All» Background Information: NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. View All» Species Reactivity:

• Rat

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with rat. Predicted to react with human and mouse based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:25 dilution from a previous lot detected NR1 in normal rat hippocampus tissue. View All» Control: Lambda phosphatase untreated and treated rat microsomal brain tissue lysates View All» Quality Assurance: Evaluated by Western Blot in lambda phosphatase untreated and treated rat microsomal brain tissue lysates.Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of lambda phosphatase untreated and treated rat microsomal brain tissue lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P35439 View All» Entrez Gene Number: NP_058706 View All» Gene Symbol:
  • GRIN1

  • Glutamate

  • NMDAR1

  • NR1

  • NMDA1
    View All» Alternate Names:
    • glutamate receptor, ionotropic, N-methyl D-aspartate 1

    • glutamate [NMDA] receptor subunit zeta 1

    • N-methyl-D-aspartate receptor channel, subunit zeta-1

    • N-methyl-D-aspartate receptor subunit NR1

    • glutamate [NMDA] receptor subunit zeta-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: Subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD]. View All» UniProt Summary: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors. SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked (By similarity). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB. Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction › synapse › postsynaptic cell membrane (By similarity). Cell junction › synapse › postsynaptic cell membrane › postsynaptic density (By similarity). Note: Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity).PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity. SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. [View classification] View All» Product Name: Anti-phospho-NR1 (Ser896) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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