货号：ABN78A4

品牌：Merck Millipore

规格：100UL

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NeuN (rabbit) Antibody, Alexa Fluor® 488 Conjugate | ABN78A4 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody recognizes NeuN at the N-terminus. View All» Molecular Weight: The unconjugated parent antibody (Cat. No. ABN78) has an observed molecular weight at ~46/48 kDa. An uncharacterized band appears at ~62 kDa in some lysates. View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to mouse NeuN. View All» Background Information: ABN78 is a rabbit polyclonal version of the Anti-NeuN, clone A60 (MAB377), NeuN is a highly characterized and cited mouse monoclonal antibody that specifically recognizes the DNA-binding, neuron-specific protein NeuN, which is present in most CNS and PNS neuronal cell types of all vertebrates tested. NeuN protein distributions are apparently restricted to neuronal nuclei, perikarya and some proximal neuronal processes in both fetal and adult brain although, some neurons fail to be recognized by NeuN at all ages: INL retinal cells, Cajal-Retzius cells, Purkinje cells, inferior olivary and dentate nucleus neurons, and sympathetic ganglion cells are examples. Immunohistochemically detectable NeuN protein first appears at developmental timepoints that correspond with the withdrawal of the neuron from the cell cycle and/or with the initiation of terminal differentiation of the neuron. Immunoreactivity appears around E9.5 in the mouse neural tube and is extensive throughout the developing nervous system by E12.5. Strong nuclear staining suggests a nuclear regulatory protein function; however, no evidence currently exists as to whether the NeuN protein antigen has a function in the distal cytoplasm or whether it is merely synthesized there before being transported back into the nucleus. No difference between protein isolated from purified nuclei and whole brain extract on immunoblots has been found. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. The unconjugated rabbit Anti-NeuN (Catalog No. ABN78) has been shown to work in human. View All» Application Notes: Immunocytochemistry analysis: A 1:100 dilution from a representative lot detected NeuN in rat E18 primary cortex cells. View All» Control: Adult mouse brain tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in adult mouse brain tissue.Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected NeuN in adult mouse brain tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» Gene Symbol: NeuN View All» Alternate Names:
  • NEUronal Nuclei

  • Neuronal Nuclei
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry
      View All» Product Name: Anti-NeuN (rabbit polyclonal), Alexa Fluor® 488 Conjugate View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Rabbit View All»
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