货号：ABN67

品牌：Merck Millipore

规格：

目录价：￥4383.00

市场价格：￥3725.55

会员价格：￥3506.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AIF-1 Antibody | ABN67 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~15 kDa observed View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human AIF-1. View All» Background Information: AIF-1 is an actin-binding protein that enhances the actin-bundling activity of LCP1 in membrane ruffling and plays a role in RAC signaling and in phagocytosis. Studies show that AIF-1 may play a role in macrophage activation and function by promoting the proliferation of T-lymphocytes and lymphocyte migration. View All» Species Reactivity:

• Human

• Rat

• Horse

• Chimpanzee

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Equine, Chimpanzee, and Rhesus Macaque based on 100% sequence homology. Other homologies: Mouse (89% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected AIF-1 in normal rat spleen tissue. View All» Control: Human lymph node tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human lymph node tissue lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected AIF-1 on 10 µg of human lymph node tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified Rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P55008 View All» Entrez Gene Number: NP_001614 View All» Gene Symbol:
  • AIF1

  • G1

  • IBA1
    View All» Alternate Names:
    • Allograft inflammatory factor 1

    • AIF-1

    • Ionized calcium-binding adapter molecule 1

    • Protein G1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. SUBUNIT STRUCTURE: Homodimer Potential. Monomer. Interacts with LCP1. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cell projection › ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.TISSUE SPECIFICITY: Detected in T-lymphocytes and peripheral blood mononuclear cells. PTM: Phosphorylated on serine residues.SEQUENCE SIMILARITIES: Contains 2 EF-hand domains. View All» Product Name: Anti-AIF-1 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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