货号：ABN57

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-10-formyltetrahydrofolate dehydrogenase Antibody | ABN57 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~100 kDa observed View All» Immunogen: Recombinant protein corresponding to rat 10-formyltetrahydrofolate dehydrogenase. View All» Background Information: 10-formyltetrahydrofolate dehydrogenase (10-FTHFDH) is also known as aldehyde dehydrogenase family 1 member L1 (ALDH1L1). 10-FTHFDH is a multidomain protein that is found in liver cytosol. It is comprised of two functionally unrelated domains, an aldehyde dehydrogenase-homologous domain and a folate-binding hydrolase domain. These two domains are thought to be connected by a 100-residue linker. 10-FTHFDH is known to induce phosphorylation of p53 at Ser6, which is a critical step in stimulating apoptosis. This process seems to be taken care of using JNK1 and JNK2. View All» Species Reactivity: Rat View All» Species Reactivity Note: Demonstrated to react with rat. View All» Control: Rat liver tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in rat liver tissue lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected 10-formyltetrahydrofolate dehydrogenase on 10 µg of rat liver tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P28037 View All» Entrez Gene Number: NP_071992 View All» Gene Symbol:

• 10-fTHF

• FTHFD

• 10-FTHFDH
  View All» Alternate Names:
  • aldehyde dehydrogenase 1 family, member L1

  • formyltetrahydrofolate dehydrogenase

  • cytosolic 10-formyltetrahydrofolate dehydrogenase

  • Aldehyde dehydrogenase family 1 member L1

  • 10-formyltetrahydrofolate dehydrogenase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Summary: Catalyzes the NADP dependent oxidation of 10-HCO-H4PteGlu to H4PteGlu and Co2 [RGD]. View All» UniProt Summary: CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + NADP+ + H2O = tetrahydrofolate + CO2 + NADPH.SUBUNIT STRUCTURE: Homotetramer.SUBCELLULAR LOCATION: Cytoplasm.SEQUENCE SIMILARITIES: In the N-terminal section; belongs to the GART family. In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. Contains 1 acyl carrier domain.CAUTION: The phosphoserine observed at Ser-354 undoubtedly results from the secondary neutral loss of pantetheine from the phosphodiester linked cofactor. View All» Product Name: Anti-10-formyltetrahydrofolate dehydrogenase View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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