货号：ABN39

品牌：Merck Millipore

规格：

目录价：￥4259.00

市场价格：￥3620.15

会员价格：￥3407.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ceruloplasmin (CP) Antibody | ABN39 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Ceruloplasmin at the F5/8 type A 3 and Plastocyanin-like 5 domains. View All» Molecular Weight: ~151 kDa observed. Spontaneous cleavage can produce three fragments with molecular masses of 67 kDa, 50 kDa, and 19 kDa which can be seen with higher concentrations and longer exposures in some lysates. (Takahashi, N., et al. (1984). Proc. Natl. Acad. Sci. USA. 81:390-394.) View All» Epitope: F5/8 type A 3 and Plastocyanin-like 5 domains View All» Immunogen: KLH-conjugated linear peptide corresponding to human Ceruloplasmin at the F5/8 type A 3 and Plastocyanin-like 5 domains. View All» Background Information: Ceruloplasmin (CP), a member of the multicopper oxidase family, is a blue, copper-binding (6-7 atoms per molecule) glycoprotein that binds 90-95% of blood plasma and is involved in iron transport across the cell membrane. Ceruloplasmin plays an important role in antioxidant protection against organic and inorganic oxygen radicals generated by iron and ascorbate. Mutations in Ceruloplasmin have been associated with Wilson’s disease and aceruloplasminemia. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Other homologies: Mouse (85% sequence homology). Rat (77% sequence homology). View All» Application Notes: Western Blot Analysis: 0.1 µg/mL from a representative lot detected Ceruloplasmin on 10 µg of HepG2 cell lysate. View All» Control: Human plasma lysate View All» Quality Assurance: Evaluated by Western Blot in human plasma lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected Ceruloplasmin on 10 µg of human plasma lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P00450 View All» Entrez Gene Number: NP_000087 View All» Gene Symbol: CP View All» Alternate Names:

• Ceruloplasmin

• Ferroxidase
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. [provided by RefSeq, Jul 2008]. View All» UniProt Summary: FUNCTION: Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane.CATALYTIC ACTIVITY: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.COFACTOR: Binds 6 copper ions per monomer.SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.INVOLVEMENT IN DISEASE: Defects in CP are the cause of aceruloplasminemia (ACERULOP) [MIM:604290]. It is an autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.Note=Ceruloplasmin levels are decreased in Wilson disease, in which copper cannot be incorporated into ceruloplasmin in liver because of defects in the copper-transporting ATPase 2.SEQUENCE SIMILARITIES: Belongs to the multicopper oxidase family.Contains 3 F5/8 type A domains.Contains 6 plastocyanin-like domains. View All» Product Name: Anti-Ceruloplasmin (CP) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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