货号：ABN100

品牌：Merck Millipore

规格：100Ug

目录价：￥5820.00

市场价格：￥4947.00

会员价格：￥4656.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody | ABN100 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of Vesicular Acetylcholine Transporter (VAChT). View All» Molecular Weight: 57 kDa calculated View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of rat VAChT. View All» Background Information: Acetylcholine mediates cholinergic transmission in the central and peripheral nervous systems, and is an important modulator of cognition, movement, and cardiovascular function, among other processes. The effects of acetylcholine are regulated by its synthesis, storage, and breakdown, which involve the related enzymes choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), and acetylcholinesterase (AChE), respectively. VAChT is primarily found in the membrane of presynaptic secretory vesicles. It contains 12 transmembrane domains and a synaptic-vesicular–targeting signal located on the intracellular C-terminal tail. The primary function of VAChT is to actively transport cytoplasmic ACh, across an electrochemical gradient, into synaptic vesicles that release ACh upon cell stimulation. The VAChT can affect cholinergic signaling by affecting the relative pools of ACh secreted to activate postsynaptic nicotinic and muscarinic receptors. VAChT is phosphorylated on its serine 480 residue in the C-terminal tail by protein kinase C. Although the precise role of this modification is still unclear, previous studies suggest that it may affect the localization of VAChT to synaptic vesicles. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. Other homologies: Human (95% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Vesicular Acetylcholine Transporter (VAChT) in rat midbrain tissue.ELISA Analysis: A representative lot detected Vesicular Acetylcholine Transporter (VAChT) in a direct ELISA using a corresponding peptide. View All» Control: Vesicular Acetylcholine Transporter (VAChT) peptide View All» Quality Assurance: Evaluated by Immunohistochemistry Analysis.Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Vesicular Acetylcholine Transporter (VAChT) in mouse midbrain tissue. View All» Purification Method: Affinity purified View All» Presentation: Purified goat polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q62666 View All» Entrez Gene Number: NP_113851 View All» Gene Symbol:
  • Slc18a3

  • Vacht

  • Vat
    View All» Alternate Names:
    • Vesicular acetylcholine transporter

    • VAChT

    • rVAT

    • Solute carrier family 18 member 3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • ELISA
        View All» Product Name: Anti-Vesicular Acetylcholine Transporter (VAChT) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Presynaptic View All» Format: Affinity Purified View All» Host: Goat View All»
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        © Merck Millipore代理ABN100 Anti-Vesicular Acetylcholine Transporter (VAChT) Antibody;抗囊泡乙酰胆碱转运蛋白（VAChT）抗体store at +2℃ to +8℃，产品报价联系微信jinshanbio