货号：ABF29

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NLRP6 (NALP6) Antibody | ABF29 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the NACHT domain of NLRP6 (NALP6). View All» Molecular Weight: ~99 kDa observed View All» Epitope: NACHT domain View All» Immunogen: Linear peptide corresponding to NACHT domain of human NLRP6 (NALP6). View All» Background Information: NRLP6 (NALP6) (also known as PYRIN-containing Apaf-1-like protein 5 or PYPAF5) belongs to a family of proteins that play a critical role in apoptosis and in inflammatory signaling. Its expression is highly restricted to granulocytes and T-cells. Co-expression of NALP6 with ASC results in synergistic activation of caspase-1-dependent cytokine processing, subsequent NF-kB activation, and downstream recruitment of PYPAF5 to punctate structures in the cytoplasm. Overlapping genes in NALP6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR. View All» Species Reactivity:

• Human

• Rat

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with Human and Rat. Predicted to react with Rhesus Macaque based on 100% sequence homology. Other homologies: Mouse (93% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected NLRP6 (NALP6) in epithelial tissue of proximal and distal tubules of human kidney, and in human bone marrow tissue. View All» Control: Rat basophilic leukemia (RBL) cell lysate View All» Quality Assurance: Evaluated by Western Blot in rat basophilic leukemia (RBL) cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NLRP6 (NALP6) in 10 µg of rat basophilic leukemia (RBL) cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P59044 View All» Entrez Gene Number: NP_612202 View All» Gene Symbol:
  • NPLPR6

  • NALP6

  • PYPAF5
    View All» Alternate Names:
    • NACHT

    • PYRIN-containing APAF1-like protein 5

    • LRR and PYD domains-containing protein 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes. View All» UniProt Summary: FUNCTION: May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B.SUBUNIT STRUCTURE: Binds to ASC with its DAPIN domain.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in granulocytes. Detected at much lower levels in T-cells. View All» Product Name: Anti-NLRP6 (NALP6) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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