货号：ABF11

品牌：Merck Millipore

规格：

目录价：￥3552.00

市场价格：￥3019.20

会员价格：￥2841.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-C4d Antibody | ABF11 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the region corresponding to C4d in the complement C4/C4b complex and its subsequent cleavage products during C4 maturation. C4b is the first cleavage product of C4, but it is difficult to visualize rapid conversion to C4d by factor I. View All» Molecular Weight: ~41 kDa observed, corresponding to the C4d cleavage product in aged mouse serum.Western Blot of mouse serum aged for different intervals revealed a band at ~200 kDa (day 0) corresponding to the molecular weight of the complement C4/C4b complex and a band at ~41 kDa (day 1) corresponding to the molecular weight of cleavage product C4d, after rapid conversion of the cleavage product C4b (Murata, K., et al., 2007). View All» Immunogen: Linear peptide corresponding to mouse C4d. View All» Isotype: IgG View All» Background Information: C4d is a degradation product of activated Complement 4 (C4), a central component in the classical complement cascade pathway. This pathway is typically activated by specific antibody binding to select target molecules, making C4d an indirect footprint or marker of antibody response. After cleavage occurs, C4d is left with several exposed ester groups that allow for C4d to bind in a transient, covalent manner to endothelial cell surfaces along with components of ECM vascular basement membranes near C4 activation sites. Due to the strength of these bonds and Cd4’s ability to act as an indirect marker of antibody response, this degradation product has become a significant marker, both general and robust, for humoral rejection of transplants including allografts from cardiac, kidney, and liver tissues. It has also been shown to bind platelets associating Cd4 as a marker for both stroke severity and ischemic stroke (Mehta, et al., 2008). View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: Aged mouse serum View All» Quality Assurance: Evaluated by Western Blot in mouse serum aged for 0 and 1 day.Western Blot Analysis: A 1:1,000 dilution of this antibody detected C4d as a singular cleavage product, as well as within the C4/C4b complex in 10 µg of aged mouse serum. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P01029 View All» Entrez Gene Number: NP_033910 View All» Gene Symbol:

• CPAMD3

• C4B5

• CO4

• C4F

• C4B2

• C4B1

• CH

• C4B12

• C4B3

• C4b
  View All» Alternate Names:
  • complement component 4B (Chido blood group)

  • basic C4

  • complement C4B1a

  • complement component 4B

  • Basic complement C4

  • Chido form of C4

  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.SUBUNIT STRUCTURE: Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.SUBCELLULAR LOCATION: Secreted. PTM: Prior to secretion, the single-chain precursor is enzymatically cleaved to yield the non-identical chains (alpha, beta and gamma). During activation, the alpha chain is cleaved by C1 into C4a and C4b, and C4b stays linked to the beta and gamma chains. Further degradation of C4b by C1 into the inactive fragments C4c and C4d blocks the generation of C3 convertase.MISCELLANEOUS: C4 is a major histocompatibility complex class-III protein.SEQUENCE SIMILARITIES: Contains 1 anaphylatoxin-like domain.Contains 1 NTR domain. View All» Product Name: Anti-C4d View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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