货号：ABE91

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JMJD8 Antibody | ABE91 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~37 kDa observed. Two isoforms with molecular weights of ~34 kDa and ~37 kDa have been described. An uncharacterized band at ~160 kDa may be observed in some lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human JMJD8. View All» Background Information: Covalent modification of histones plays critical role in regulating chromatin structure and transcription. JMJD8 is one member of the family of JmjC domain-containing histone demethylation (JHDM) enzymes. These proteins remove specific methyl marks from histones. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed. While two isoforms of JMJD8 have been described, further study is still required to clarify the roles and mechanisms of JMJD8 among other JHDM protein family members. View All» Species Reactivity:

• Human

• Pig

• Chimpanzee

• Rhesus Macaque

• Canine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Porcine, Chimpanzee, Rhesus Macaque, Canine, and Equine based on 100% sequence homology. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1 mg/mL of this antibody dected JMJD8 in 10 mg of HeLa nuclear extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96S16 View All» Entrez Gene Number: NP_001005920.2 View All» Gene Symbol:
  • JMJD8

  • C16orf20

  • PP14397
    View All» Alternate Names:
    • JMJD

    • JmjC domain-containing protein 8

    • Jumonji domain-containing protein 8
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Product Name: Anti-JMJD8 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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