货号：ABE77

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Yin and yang 1 Antibody | ABE77 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 55 kDa observed. View All» Epitope: N/A View All» Immunogen: Full length recombinant protein corresponding to human Yin and yang 1. View All» Background Information: Yin and yang 1 (YY-1) is a highly conserved, zinc finger protein belonging to the YY transcription factor family and that functions, depending on the promoter context, as either a transcriptional activator, a transcriptional repressor, or a functional modifier for other proteins, or. YY-1 contains 4 C2H2-type zinc fingers and plays a role in regulating numerous cellular and viral genes participating in the directing of cellular process such as; growth, differentiation, development, and also tumor suppression. Through its ability to interact with and bind to different transcription factors and transcriptional regulators, YY-1 can influence a wide range of activities. For example, studies have shown YY-1 to up-regulate DR5 expression in TRAIL-induced apoptosis, and to inhibit skeletal α-actin muscle-restricted transcription through the relegation of SRF. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Yin and yang 1 in NIH/3T3 and A431 cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Yin and yang 1 on 10 µg of HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P25490 View All» Entrez Gene Number: NP_003394 View All» Gene Symbol:
  • YY-1

  • YY1

  • DELTA
    View All» Alternate Names:
    • YY1 transcription factor

    • Delta transcription factor

    • INO80 complex subunit S

    • YIN-YANG-1

    • transcriptional repressor protein YY1

    • Yin and Yang 1 protein

    • Yin and yang 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. May play an important role in development and differentiation. The function of YY1 as an activator or a repressor is specified by the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.SUBUNIT STRUCTURE: Interacts with YAF2 through the region encompassing the first and second zinc fingers. Interacts with INO80. SUBCELLULAR LOCATION: Nucleus matrix. Note: Associated with the nuclear matrix. SEQUENCE SIMILARITIES: Belongs to the YY transcription factor family.Contains 4 C2H2-type zinc fingers. View All» Product Name: Anti-Yin and yang 1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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