货号：ABE73

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FoxP2 Antibody | ABE73 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FoxP2. View All» Molecular Weight: 80 and 77 kDa Observed. Alternative splicing can result in cell type dependent isoforms. View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to mouse FoxP2. View All» Isotype: IgG View All» Background Information: Forkhead box protein P2 (FoxP2) is a multidomain transcriptional repressor that belongs to the Fox family of proteins. The FoxP2 protein contains a forkhead-box DNA-binding domain, characteristic of the FOX group of transcription factors. In addition, this protein contains a polyglutamine tract, as well as zinc finger and leucine zipper motifs. In order for FoxP2 to bind DNA, it forms homodimers and heterodimers with FoxP1 and FoxP4. The forkhead box family of proteins play an important role in immune response, organ development and the development of cancer. Functional studies in vertebrates suggest this with this gene plays a role in the modulation neural plasticity. In line with these findings, mutations of FoxP2 in humans have been linked to speech and language disorders. View All» Species Reactivity:

• Mouse

• Rabbit

• Human
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rabbit. View All» Application Notes: Western Blot Analysis: 1:1,000 dilution from a representative lot detected FoxP2 in 10 µg of L6, NIH/3T3, mouse brain, rat brain, and human brain lysates.Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.) View All» Control: RAW264.7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in RAW264.7 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP2 on 10 µg of RAW264.7 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P58463 View All» Entrez Gene Number: NP_444472 View All» Gene Symbol:
  • CAGH44

  • TNRC10

  • SPCH1
    View All» Alternate Names:
    • forkhead box P2

    • trinucleotide repeat containing 10

    • CAG repeat protein 44

    • forkhead/winged-helix transcription factor

    • Trinucleotide repeat-containing gene 10 protein

    • speech and language disorder 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICITY: Highest expression in lung. Lower expression in spleen, skeletal muscle, brain, kidney and small intestine.DEVELOPMENTAL STAGE: Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed at a high level in the distal airway epithelium and at a low level in the proximal airway epithelium at 12.5 dpc, and restricted to the distal airway epithelium by 14.5 dpc. In the spinal cord, at 12.5 dpc, expressed in a subset of interneurons dorsal to motor neurons. At 16.5 dpc, expression in the brain is observed in the inner intermediate zone of the neopallial cortex and in the developing cerebral hemispheres. In the gastrointestinal system, at 12.5 expressed in the outer mesodermal layer and in the intestinal epithelium. By 16.5 dpc, expression is restricted to the outer longitudinal muscle layer of the intestine and stomach. In the cardiovascular system, at 14.5 dpc, expressed in the outflow tract region of the developing heart. By 16.5 dpc, observed in the outflow tract and atrium, but not in the ventricles. DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression. SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-FoxP2 Antibody (ABE73) View All» Concentration: n/a mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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