货号：ABE68

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FoxP1 Antibody | ABE68 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes FoxP1. View All» Molecular Weight: 79 kDa observed. Alternative splicing can result in cell type dependent isoforms. View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to mouse FoxP1. View All» Isotype: IgG View All» Background Information: Forkhead Box P1 (FoxP1) is a member of the FOX family of transcription factors. This protein is known to forms homodimers and heterodimers with family members FoxP2 and FoxP4. The forkhead box family has a broad range of functions. These proteins play important roles in immune response, organ development and the development of cancer. The FoxP1 protein is widely expressed and contains both forkhead (winged-helix) and C2H2 zinc finger nucleic acid-binding motifs. At least four different isoforms that result from alternative splicing of the mRNA transcript have been reported. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FoxP1 in HeLa and NIH/3T3 cells.Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.) View All» Control: RAW264.7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in RAW264.7 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP1 on 10 µg of RAW264.7 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P58462 View All» Entrez Gene Number: NP_444432 View All» Gene Symbol:
  • Foxp1

  • QRF1
    View All» Alternate Names:
    • forkhead box P1

    • fork head-related protein like B

    • glutamine-rich factor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Transcriptional repressor that plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B cell development.SUBUNIT STRUCTURE: Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Highest expression in the lung, brain, and spleen. Lower expression in heart, skeletal muscle, kidney, small intestine (isoform 3 not present) and liver.DEVELOPMENTAL STAGE: Expressed in developing lung, neural, intestinal and cardiovascular tissues. Expressed in both the airway epithelium of the forming lung as well as in the surrounding mesenchyme. By 16.5 dpc, expressed throughout the conducting airway epithelium, with highest expression in the distal alveolar regions. Also expressed in the endotheial cells of the pulmonary vasculature. During intestinal development, expressed in the mucosal layer but absent from the epithelium at 12.5 dpc. By 16.5 dpc, expressed in both the inner circular and outer longitudinal muscular layers of the intestine as well as in the epithelium of the intestine and developing stomach. DOMAIN: The leucine-zipper is required for dimerization and transcriptional repression. SEQUENCE SIMILARITIES: Contains 1 C2H2-type zinc finger.Contains 1 fork-head DNA-binding domain. View All» Product Name: Anti-FoxP1 Antibody (ABE68) View All» Concentration: n/a mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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