货号：ABE289

品牌：Merck Millipore

规格：100Y56

目录价：￥4594.00

市场价格：￥3904.90

会员价格：￥3675.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-trimethyl-Histone H3 (Lys18) Antibody | ABE289 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H3 trimethylated at Lys18. View All» Molecular Weight: ~17 kDa observed View All» Epitope: Trimethylated at Lys18 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Histone H3 trimethylated at Lys18. View All» Modifications: Methylation View All» Background Information: Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H3 is involved with the structure of the nucleosomes of the 'beads on a string' structure. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. View All» Control: Synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3. View All» Quality Assurance: Evaluated by Western Blot in synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3.Western Blot Analysis: A 1:2,000 dilution of this antibody detected trimethyl-Histone H3 in 0.5 µg of synthetic, monomethyl-, dimethyl-, and trimethyl-Histone H3. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q93081 View All» Entrez Gene Number: NP_003520 View All» Gene Symbol:
  • HIST1H3A

  • H3FA

  • HIST1H3B

  • H3FL

  • HIST1H3C

  • H3FC

  • HIST1H3D

  • H3FB

  • HIST1H3E

  • H3FD

  • HIST1H3F

  • H3FI

  • HIST1H3G

  • H3FH

  • HIST1H3H

  • H3FK

  • HIST1H3I

  • H3FF

  • HIST1H3J

  • H3FJ
    View All» Alternate Names:
    • H3K18me3

    • Histone H3.1

    • Histone H3/a

    • Histone H3/b

    • Histone H3/c

    • Histone H3/d

    • Histone H3/f

    • Histone H3/h

    • Histone H3/I

    • Histone H3/j

    • Histone H3/k

    • Histone H3/l
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. View All» UniProt Summary: FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus. Chromosome. View All» Product Name: Anti-trimethyl-Histone H3 (Lys18) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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