货号：ABE263

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NRMT Antibody | ABE263 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~25 kDa observed. Two isoforms at16 kDa and 25 kDa are known to exist. Uncharacterized bands may be observed above ~40 kDa in some cell lysates. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human NRMT. View All» Background Information: NRMT is an alpha-N-methyltransferase that methylates RCC1, SET (TAF-1 or PHAP-2), and RB (retinoblastoma protein). It is shown that the effects of NRMT knockdown resemble a multi-spindle phenotype, which is characteristic of methylation-defected RCC1 mutants. As such, it is suggested that NMRT plays an important role in bipolar spindle formation, and chromosome segregation. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat, and Mouse based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected NRMT in A431 cells. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected NRMT in 10 µg of HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal in serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9BV86 View All» Entrez Gene Number: NP_054783 View All» Gene Symbol:
  • METTL11A

  • C9orf32

  • NRMT

  • NTMT1
    View All» Alternate Names:
    • Alpha N-terminal protein methyltransferase 1A

    • Methyltransferase-like protein 11A

    • N-terminal RCC1 methyltransferase

    • X-Pro-Lys N-terminal protein methyltransferase 1A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200). View All» UniProt Summary: FUNCTION: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.CATALYTIC ACTIVITY: S-adenosyl-L-methionine + N-terminal-XPK-[protein] = S-adenosyl-L-homocysteine + methyl-N-XPK-[protein]. S-adenosyl-L-methionine + methyl-N-XPK-[protein] = S-adenosyl-L-homocysteine + dimethyl-N-XPK-[protein]. S-adenosyl-L-methionine + dimethyl-N-YPK-serine-[protein] S-adenosyl-L-homocysteine + trimethyl-N-YPK-[protein].SUBCELLULAR LOCATION: Nucleus. Note: Predominantly nuclear. View All» Product Name: Anti-NRMT View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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