货号：ABE212

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Set1A Antibody | ABE212 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~186 kDa observed. A cross-reacting band appears at ~45 kDa. View All» Immunogen: GST-tagged recombinant protein corresponding to human Set1A. View All» Background Information: Set1A is a histone methyltransferase (HMT) that is part of the SET1 HMT complex. This protein specifically methylates lysine 4 of histone H3 if the adjacent lysine at position 9 is also unmethylated. Studies demonstrate that Set1A and Set1B localize to largely non-overlapping regions of the chromosome. This suggests Set1A and Set1B bind to unique sets of target genes and that each protien makes non-redundant contributions to the epigenetic control of chromatin structure and gene expression. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Chromatin Immunoprecipitation (ChIP):A representative lot of this antibody was reported to work in ChIP. See Lee, J.H., et al.(2008). Mol Cell Biol. 28(2):609–618.Immunocytochemistry: A representative lot of this antibody was reported to work in immunocytochemistry. See . Lee, J.H., et al. (2007). J Biol Chem. 282(18):13419-13428. View All» Control: PC3 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC3 cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected Set1A on 10 µg of PC3 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O15047 View All» Entrez Gene Number: NP_055527 View All» Gene Symbol:
  • hSET1A

  • SET1

  • SET1A

  • SETD1A

  • Set1

  • Set1A
    View All» Alternate Names:
    • SET domain containing 1A

    • Lysine N-methyltransferase 2F

    • histone-lysine N-methyltransferase SETD1A

    • Set1/Ash2 histone methyltransferase complex subunit SET1

    • SET domain-containing protein 1A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: SET1A is a component of a histone methyltransferase (HMT) complex that produces mono-, di-, and trimethylated histone H3 at Lys4. The complex is the analog of the S. cerevisiae Set1/COMPASS complex (Lee and Skalnik, 2005 [PubMed 16253997]). View All» UniProt Summary: FUNCTION: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SUBUNIT STRUCTURE: Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. SUBCELLULAR LOCATION: Nucleus speckle. Chromosome. Note: Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1B, suggesting that SETD1A and SETD1B each bind to a unique set of target genes.SEQUENCE SIMILARITIES: Contains 1 post-SET domain.Contains 1 RRM (RNA recognition motif) domain.Contains 1 SET domain.SEQUENCE CAUTION: The sequence AAH27450.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH35795.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.The sequence BAA20797.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Set1A View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://16ao.com/thread-158961.htm
      © Merck Millipore代理ABE212 Anti-Set1A Antibody;store at -20℃，产品报价联系微信jinshanbio