货号：ABE211

品牌：Merck Millipore

规格：100UL

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CFP1 Antibody | ABE211 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~78 kDa observed. A cross-reacting band observed at ~110 kDa. View All» Immunogen: GST-tagged recombinant protein corresponding to human CFP1. View All» Background Information: CXXC finger protein 1 (CFP1) is part of the Setd1A and Setd1B methyltransferase compounds. Research shows that CFP1 also interacts with the cytosine methylation mechanism. CFP1 is necessary for development of mammals and is a key regulator of chromatin structure. Embryonic stem cells that are missing CFP1 are more susceptible to DNA-damaging agents and tend to build up more DNA damage. CFP1 has been shown to also be a regulator of DNA repair. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human and rat. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1:1,000 dilution of this antibody detected CFP1 on 10 µg of HeLa nuclear extract. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9P0U4 View All» Entrez Gene Number: NP_055408 View All» Gene Symbol:
  • CXXC1

  • CGBP

  • PHF18

  • PCCX1

  • CFP1

  • SPP1

  • hCGBP

  • ZCGPC1
    View All» Alternate Names:
    • CXXC finger 1 (PHD domain)

    • PHD finger and CXXC domain-containing protein 1

    • CXXC-type zinc finger protein 1

    • cpG-binding protein

    • CpG binding protein

    • zinc finger, CpG binding-type containing 1

    • DNA-binding protein with PHD finger and CXXC domain
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression (Carlone and Skalnik, 2001 [PubMed 11604496]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Transcriptional activator that exhibits a unique DNA binding specificity for [AC]CpG[AC] unmethylated CpG motifs.SUBUNIT STRUCTURE: Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1.SUBCELLULAR LOCATION: Nucleus speckle. Note: Associated with euchromatin. During mitosis, excluded from condensed chromosomes. TISSUE SPECIFICTY: Ubiquitous.DOMAIN: The acidic domain carries the potential to activate transcription. PTM: May be regulated by proteolysis.SEQUENCE SIMILARITIES: Contains 1 CXXC-type zinc finger.Contains 1 PHD-type zinc finger. View All» Product Name: Anti-CFP1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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