货号：ABE210

品牌：Merck Millipore

规格：100UL

目录价：￥4146.00

市场价格：￥3524.10

会员价格：￥3316.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRF1 Antibody | ABE210 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 58 kDa observed View All» Immunogen: GST-tagged recombinant protein corresponding to mouse TRF1. View All» Background Information: TTAGGG repeat-binding factor 1, also known as Telomeric repeat-binding factor 1 and TRF1, is a telomere specific protein localized to the ends of mammalian chromosomes. TRF1 is is part of a the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1 gene products. As part of this complex the TRF1 protien binds to telomeric TTAGGG repeats and facilitates negative regulation of telomere length by acting in cis to inhibit telomerase thus limiting the elongation of individual chromosome ends. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. View All» Control: Human placenta cell lysate View All» Quality Assurance: Evaluated by Western Blot in human placenta cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected TRF1 on 10 µg of human placenta cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P70371 View All» Entrez Gene Number: NP_033378 View All» Gene Symbol:
  • TRF1

  • Terf1
    View All» Alternate Names:
    • Telomeric repeat-binding factor 1

    • TTAGGG repeat-binding factor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways (By similarity).SUBUNIT STRUCTURE: Homodimer; can contain both isoforms. Found in a complex with POT1; TINF2 and TNKS1. Interacts with ATM, TINF2, TNKS1, TNKS2, PINX1, NEK2 and MAPRE1. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Interacts with RLIM (via N-terminus). Interacts with FBXO4. Interaction with TINF2 protects against interaction with FBXO4 and subsequent polyubiquitination and proteasomal degradation (By similarity).SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome › telomere (By similarity). Cytoplasm › cytoskeleton › spindle (By similarity). Note: Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle (By similarity).DOMAIN: The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules (By similarity).The TRFH dimerization region mediates the interaction with TINF2 (By similarity).PTM: Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage (By similarity).ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA (By similarity).Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome (By similarity).SEQUENCE SIMILARITIES: Contains 1 HTH myb-type DNA-binding domain. View All» Product Name: Anti-TRF1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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